abstract：:Divalent copper and iron cations have been acknowledged for their catalytic roles in physiological processes critical for homeostasis maintenance. Being redox-active, these metals act as cofactors in the enzymatic reactions of electron transfer. However, under pathophysiological conditions, owing to their high redox p...

journal_title：Redox biology

authors： Jakubowska MA,Pyka J,Michalczyk-Wetula D,Baczyński K,Cieśla M,Susz A,Ferdek PE,Płonka BK,Fiedor L,Płonka PM

更新日期：2020-07-01 00:00:00

abstract：:Oxidation-reduction chemistry is fundamental to the metabolism of all living organisms, and hence quantifying the principal redox players is important for a comprehensive understanding of cell metabolism in normal and pathological states. In mammalian cells, this is accomplished by measuring oxygen partial pressure (p...

journal_title：Redox biology

authors： Penjweini R,Roarke B,Alspaugh G,Gevorgyan A,Andreoni A,Pasut A,Sackett DL,Knutson JR

更新日期：2020-07-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor regulating the expression of genes, for instance encoding the monooxygenases cytochrome P450 (CYP) 1A1 and CYP1A2, which are important enzymes in metabolism of xenobiotics. The AHR is activated upon binding of polycyclic aromatic hydrocarbo...

journal_title：Redox biology

authors： Vogel CFA,Van Winkle LS,Esser C,Haarmann-Stemmann T

更新日期：2020-07-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death and disability worldwide with increased oxidative stress and reduced NO bioavailability serving as key risk factors. For decades, elevation in protein abundance and enzymatic activity of xanthine oxidoreductase (XOR) under hypoxic/inflammatory conditions has been as...

journal_title：Redox biology

authors： Pardue S,Kolluru GK,Shen X,Lewis SE,Saffle CB,Kelley EE,Kevil CG

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Cellular repressor of E1A-stimulated genes (CREG), a vasculoprotective molecule, is significantly downregulated in atherosclerotic vessels through unclear mechanisms. While epigenetic regulation is involved in atherosclerosis development, it is not known if the CREG gene is epigenetically regulated. The aim o...

journal_title：Redox biology

authors： Liu Y,Tian X,Liu S,Liu D,Li Y,Liu M,Zhang X,Yan C,Han Y

更新日期：2020-05-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of the death for both men and women. Although baseline heart physiology and the response to disease are known to differ by sex, little is known about sex differences in baseline molecular signaling, especially with regard to redox biology. In this review, we describe current...

journal_title：Redox biology

authors： Casin KM,Kohr MJ

更新日期：2020-04-01 00:00:00

abstract：:Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females, which has been li...

journal_title：Redox biology

authors： Torrens-Mas M,Pons DG,Sastre-Serra J,Oliver J,Roca P

更新日期：2020-04-01 00:00:00

abstract：:Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species ...

journal_title：Redox biology

authors： Torrente L,Prieto-Farigua N,Falzone A,Elkins CM,Boothman DA,Haura EB,DeNicola GM

更新日期：2020-02-01 00:00:00

abstract：:FUN14 domain-containing protein 1 (Fundc1)-dependent mitophagy, mainly activated by ischemic/hypoxic preconditioning, benefits acute myocardial reperfusion injury and chronic metabolic syndrome via sustaining mitochondrial homeostasis. Mitochondrial fission plays a pathogenic role in ischemic acute kidney injury (AKI)...

journal_title：Redox biology

authors： Wang J,Zhu P,Li R,Ren J,Zhou H

更新日期：2020-02-01 00:00:00

abstract：:Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent and apoptotic fate remains, however, poorly recognized. Nrf2 is an important transcription factor orchestrating adaptive response to cellular stress. H...

journal_title：Redox biology

authors： Kopacz A,Klóska D,Proniewski B,Cysewski D,Personnic N,Piechota-Polańczyk A,Kaczara P,Zakrzewska A,Forman HJ,Dulak J,Józkowicz A,Grochot-Przęczek A

更新日期：2020-01-01 00:00:00

abstract：:Glutathione peroxidase 2 (GPx2) is one of the five selenoprotein GPxs having a selenocysteine in the active center. GPx2 is strongly expressed in the gastrointestinal epithelium, as is another isoform, GPx1, though with a different localization pattern. Both GPxs are redox-active enzymes that are important for the red...

journal_title：Redox biology

authors： Koeberle SC,Gollowitzer A,Laoukili J,Kranenburg O,Werz O,Koeberle A,Kipp AP

更新日期：2020-01-01 00:00:00

abstract：:Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with 'peroxiporin' activity (AQP3, AQP8, AQP9). Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also A...

journal_title：Redox biology

authors： Bestetti S,Galli M,Sorrentino I,Pinton P,Rimessi A,Sitia R,Medraño-Fernandez I

更新日期：2020-01-01 00:00:00

abstract：:The NADPH oxidase reaction produces protons. In the case of the NADPH oxidase, NOX2, activity depends on secretion of these protons and is inhibited by blockade of the voltage-gated proton channel (Hv1). Duox1 and Duox2 activities similarly produce intracellular protons but synthesize hydrogen peroxide directly instea...

journal_title：Redox biology

authors： Gattas MV,Jaffe A,Barahona J,Conner GE

更新日期：2020-01-01 00:00:00

abstract：:Oxidative modification of cysteine residues has been shown to regulate the activity of several protein-tyrosine kinases. We explored the possibility that Fms-like tyrosine kinase 3 (FLT3), a hematopoietic receptor-tyrosine kinase, is subject to this type of regulation. An underlying rationale was that the FLT3 gene is...

journal_title：Redox biology

authors： Böhmer A,Barz S,Schwab K,Kolbe U,Gabel A,Kirkpatrick J,Ohlenschläger O,Görlach M,Böhmer FD

更新日期：2020-01-01 00:00:00

abstract：:Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling...

journal_title：Redox biology

authors： Xie K,Varatnitskaya M,Maghnouj A,Bader V,Winklhofer KF,Hahn S,Leichert LI

更新日期：2020-01-01 00:00:00

abstract：:Emerging evidence suggests that oroxylin A exhibits antitumor effects by inducing cell apoptosis. However, the involved molecular mechanisms have not been elucidated. Here we report that the apoptosis induced by oroxylin A was dependent on p62-mediated activation of caspase-8 in hepatocellular carcinoma cells. Further...

journal_title：Redox biology

authors： Zhao Y,Zhu Q,Bu X,Zhou Y,Bai D,Guo Q,Gao Y,Lu N

更新日期：2020-01-01 00:00:00

abstract：:Hypertonia is pathognomonic of cerebral palsy (CP), often caused by brain injury before birth. To understand the early driving events of hypertonia, we utilized magnetic resonance imaging (MRI) assessment of early critical brain injury in rabbit fetuses (79% term) that will predict hypertonia after birth following ant...

journal_title：Redox biology

authors： Vasquez-Vivar J,Shi Z,Jeong JW,Luo K,Sharma A,Thirugnanam K,Tan S

更新日期：2020-01-01 00:00:00

abstract：:It has been shown that anti-inflammatory cytokines interleukin-35 (IL-35) and IL-10 could inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what pathways IL-35 and IL-10 could block atherogenic lipid lysophosphatidylcholine (LPC)-induced sustained EC activation; and if mitochondrial...

journal_title：Redox biology

authors： Li X,Fang P,Sun Y,Shao Y,Yang WY,Jiang X,Wang H,Yang X

更新日期：2020-01-01 00:00:00

abstract：:We present a new database, specifically devoted to ROS homeostasis regulated proteins. This database replaced our previous database, the PeroxiBase, which was focused only on various peroxidase families. The addition of 20 new protein families related with ROS homeostasis justifies the new name for this more complex a...

journal_title：Redox biology

authors： Savelli B,Li Q,Webber M,Jemmat AM,Robitaille A,Zamocky M,Mathé C,Dunand C

更新日期：2019-09-01 00:00:00

abstract：:Hypertension is one of the major predisposing factors for neurodegenerative disease characterized with activated renin-angiotensin system (RAS) in both periphery and brain. Vitamin D (VitD) is recently recognized as a pleiotropic hormone with strong neuroprotective properties. While multiple lines of evidence suggest ...

journal_title：Redox biology

authors： Cui C,Xu P,Li G,Qiao Y,Han W,Geng C,Liao D,Yang M,Chen D,Jiang P

更新日期：2019-09-01 00:00:00

abstract：:Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjugated with GSH by glutathione-s-transferase (GST) to form a fluorescen...

journal_title：Redox biology

authors： Rastogi A,Clark CW,Conlin SM,Brown SE,Timme-Laragy AR

更新日期：2019-09-01 00:00:00

abstract：:Glucose starvation is one of the major forms of metabolic stress in cancer cells. Deprivation of glucose impairs glycolysis and the pentose phosphate pathway, which elicits oxidative stress due to enhanced production of reactive oxygen species (ROS) and impaired antioxidant system, leading to redox imbalance and cell ...

journal_title：Redox biology

authors： Ren Y,Shen HM

更新日期：2019-07-01 00:00:00

abstract：:Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintain proteostasis. Here, we report that hippocampal cells selected for f...

journal_title：Redox biology

authors： Chakraborty D,Felzen V,Hiebel C,Stürner E,Perumal N,Manicam C,Sehn E,Grus F,Wolfrum U,Behl C

更新日期：2019-06-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world. Recent evidence suggests that RPE and photoreceptors have an interconnected metabolism and that mitochondrial damage in RPE is a trigger for degeneration in both RPE and photoreceptors in AMD. To test this hypothesis, this...

journal_title：Redox biology

authors： Brown EE,DeWeerd AJ,Ildefonso CJ,Lewin AS,Ash JD

更新日期：2019-06-01 00:00:00

abstract：:The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytes-macrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern. Acetylation and phosphorylation of HMGB1 are implicated in the regulation of its nucleocytoplasmic translocation for secretion, although in...

journal_title：Redox biology

authors： Kwak MS,Kim HS,Lkhamsuren K,Kim YH,Han MG,Shin JM,Park IH,Rhee WJ,Lee SK,Rhee SG,Shin JS

更新日期：2019-06-01 00:00:00

abstract：:Sulfane sulfur is common inside cells, playing both regulatory and antioxidant roles. However, there are unresolved issues about its chemistry and biochemistry. We report the discovery that reactive sulfane sulfur such as polysulfides and persulfides could be detected by using resonance synchronous spectroscopy (RS2)....

journal_title：Redox biology

authors： Li H,Liu H,Chen Z,Zhao R,Wang Q,Ran M,Xia Y,Hu X,Liu J,Xian M,Xun L

更新日期：2019-06-01 00:00:00

abstract：:Hypoxia, a common element in the tumor environment, leads to Hypoxia-Inducible Factor-1α (HIF-1α) stabilization to modulate cellular metabolism as an adaptive response. In a previous study, we showed that inhibition of the nuclear factor erythroid 2-like-2 (NFE2L2; NRF2), a master regulator of many genes coping with e...

journal_title：Redox biology

authors： Lee S,Hallis SP,Jung KA,Ryu D,Kwak MK

更新日期：2019-06-01 00:00:00

abstract：:Ferroptosis is an outcome of metabolic disorders and closely linked to liver cancer. However, the mechanism underlying the fine regulation of ferroptosis in liver cancer remains unclear. Here, we have identified two categories of genes: ferroptosis up-regulated factors (FUF) and ferroptosis down-regulated factors (FDF...

journal_title：Redox biology

authors： Zhang X,Du L,Qiao Y,Zhang X,Zheng W,Wu Q,Chen Y,Zhu G,Liu Y,Bian Z,Guo S,Yang Y,Ma L,Yu Y,Pan Q,Sun F,Wang J

更新日期：2019-06-01 00:00:00

abstract：:Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. Mutation of these residues results in strains with increased resistance to disulfide stress. I...

journal_title：Redox biology

authors： Vall-Llaura N,Mir N,Garrido L,Vived C,Cabiscol E

更新日期：2019-06-01 00:00:00

abstract：:Ischemia/reperfusion injury (I/R) is one of the leading causes of acute kidney injury (AKI) that typically occurs in renal surgeries. However, renal I/R still currently lacks effective therapeutic targets. In this study, we proved that inhibition of Brd4 with its selective inhibitor, JQ1, could exert a protective role...

journal_title：Redox biology

authors： Liu H,Wang L,Weng X,Chen H,Du Y,Diao C,Chen Z,Liu X

更新日期：2019-06-01 00:00:00

abstract：:Cells employ multiple defence mechanisms to sustain a wide range of stress conditions associated with accumulation of modified self-biomolecules leading to lipo- and proteotoxicity. One of such mechanisms involves activation of the autophagy-lysosomal pathway for removal and degradation of modified lipids, proteins an...

journal_title：Redox biology

authors： Coliva G,Duarte S,Pérez-Sala D,Fedorova M

更新日期：2019-05-01 00:00:00

abstract：:Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase of PM2.5 of 10 μg per cubic meter was associated with a 76% increase in the ris...

journal_title：Redox biology

authors： Yue W,Tong L,Liu X,Weng X,Chen X,Wang D,Dudley SC,Weir EK,Ding W,Lu Z,Xu Y,Chen Y

更新日期：2019-04-01 00:00:00

abstract：:Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies have shown that one member, PDIA3, interacts with influenza A virus (IAV) hemagglutinin (HA), and this interaction is required for efficient oxidative folding of...

journal_title：Redox biology

authors： Chamberlain N,Korwin-Mihavics BR,Nakada EM,Bruno SR,Heppner DE,Chapman DG,Hoffman SM,van der Vliet A,Suratt BT,Dienz O,Alcorn JF,Anathy V

更新日期：2019-04-01 00:00:00

abstract：:Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced neointima hyperplasia and the under...

journal_title：Redox biology

authors： Wu W,Zhang W,Choi M,Zhao J,Gao P,Xue M,Singer HA,Jourd'heuil D,Long X

更新日期：2019-04-01 00:00:00

abstract：:Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis characterized by its insensitivity to chemotherapy. Emerging evidence indicates that cytoprotective antioxidation is involved in drug resistance of various cancers; however, the underlying molecular mechanisms remain obscure. Here, we ...

journal_title：Redox biology

authors： Tian L,Lu Y,Yang T,Deng Z,Xu L,Yao W,Ma C,Li X,Zhang J,Liu Y,Wang J

更新日期：2019-04-01 00:00:00

abstract：:Adult progenitor cells reside in specialized microenvironments which maintain their undifferentiated cell state and trigger regenerative responses following injury. Although these environments are well described in several tissues, the cellular components that comprise the cardiac environment where progenitor cells ar...

journal_title：Redox biology

authors： Herrero D,Cañón S,Albericio G,Carmona RM,Aguilar S,Mañes S,Bernad A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:While statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences in oxidatively generated nucleotide damage and chronic inflammation, and the relationship between nucleotide damage and chronic inflammation. METHODS...

journal_title：Redox biology

authors： Sørensen AL,Hasselbalch HC,Nielsen CH,Poulsen HE,Ellervik C

更新日期：2019-02-01 00:00:00

abstract：:Transcription factors control the rate of transcription of genetic information from DNA to messenger RNA, by binding specific DNA sequences in promoter regions. Transcriptional gene control is a rate-limiting process that is tightly regulated and based on transient environmental signals which are translated into long-...

journal_title：Redox biology

authors： Hopkins BL,Neumann CA

更新日期：2019-02-01 00:00:00

abstract：:We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration. However, delivery of naked siRNA remains a formidable challenge...

journal_title：Redox biology

authors： Xu Y,Pang L,Wang H,Xu C,Shah H,Guo P,Shu D,Qian SY

更新日期：2019-02-01 00:00:00

abstract：:Gastric cancer is one of the leading causes of cancer-related deaths. Chemotherapy has improved long-term survival of patients with gastric cancer. Unfortunately, cancer readily develops resistance to apoptosis-inducing agents. New mechanisms, inducing caspase-independent paraptosis-like cell death in cancer cells is ...

journal_title：Redox biology

authors： Chen X,Chen X,Zhang X,Wang L,Cao P,Rajamanickam V,Wu C,Zhou H,Cai Y,Liang G,Wang Y

更新日期：2019-02-01 00:00:00